Certification: | ISO9001 |
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Grade Standard: | Medicine Grade |
Type: | Chemical Reagent |
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Product Name:Crospovidone Chemical Description:Croslinked PVP,Crospovidone,Insoluble PVPPollyvinylpolypyrrolidone INCI/CTFA:Insoluble PVP Pharmacopeia Name:Crospovidone (Crospovidonum) CAS NO.:9003-39-8,25249-54-1 Formula Structure:
Product Properties: Crospovidone is hygroscopic,insoluble in water and all other common solvents,but it swells rapidly in aqueous solutbition without any gel froms.Its; classified as Crospovidone Type A and Type B according to the different particle size.
Specifications:
Applications: In the pharmaceutical industry,Crospovidone are widely used as 1)Disintergrating agent, 2)Stabilizer for suspension, 3)Moisture Absorbent, 4)Complextant of Polyphenols and Tannin for the extract formulations. |
Product |
Crospovidone Type A |
Crospovidone Type B |
Appearance |
White or yellowish-white powder or flakes |
|
Identifications |
Meet ID Tests |
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Solubility |
Practically insoluble in water,in alcohol and in methylene chloride |
|
Water- soluble substances |
1.0% max |
1.0% max |
pH((1% in water) |
5.0 -8.0 |
5.0 -8.0 |
Loss on Drying |
5.0% max. |
5.0% max. |
Sulphated Ash |
0.1% max. |
0.1% max. |
Nitrogen content |
11.0 -12.8 % |
11.0 -12.8 % |
Impurity A |
10 ppm max. |
10 ppm max. |
Peroxide(As H2O2) |
400 ppm max. |
1000 ppm max. |
Heavy Metal |
10 ppm max. |
10 ppm max. |
Particle Size(μm), ≥80% |
50-300 |
5-50 |
TEST ITEMS |
SPECIFICATIONS | TEST VALUE |
Appearance | White powder | Complies |
Soluble components % | < 1.5 | 0.29 |
Loss on drying % | ≤ 5.0 | 3.25 |
N-vinylpyrrolidone ppm | ≤ 10 | < 10 |
PH value (1% in water) | 5-8 | 6.85 |
Arsenic ppm | ≤ 3 | < 3 |
Moisture % | < 5.0 | 3.59 |
Sulfateash % | < 0.2 | 0.035 |
Nitrogen content % | 11.0-12.8 | 11.65 |
Heavy metal (as Pb) ppm | ≤ 10 | < 10 |
Peroxides(as H2O2) ppm | ≤ 400 | < 400 |